Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced fibrinolytic potential in mice with combined homozygous deficiency of alpha2-antiplasmin and PAI-1.

Thrombosis and haemostasis - 1 Aug 2001

Dewerchin M, Collen D, Lijnen H R

Abstract excerpt

Alpha2-antiplasmin (alpha2-AP) and plasminogen activator inhibitor-1 (PAI-1) are the main physiological inhibitors of the plasminogen/plasmin system in mammalian plasma. In the present study, the relative importance of both inhibitors was evaluated with the use of mice with single or combined deficiency of alpha2-AP and PAI-1 in the same genetic background. Mice with combined deficiency (alpha2-AP-/-:PAI-1-/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endotoxins
Share to Fibrin
Share to Fibrinolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Kidney

Share to Mice, Mutant Strains

Share to Plasminogen Activator Inhibitor 1

Share to Serine Proteinase Inhibitors

Source

Identifiers

PMID: 11522016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced fibrinolytic potential in mice with combined homozygous deficiency of alpha2-antiplasmin and PAI-1.PMID 11522016Read ↗

Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding.Semantic proximity Read ↗

Gene targeting in hemostasis. Alpha2-antiplasmin.Semantic proximity Read ↗

Genetic interactions between the coagulation and fibrinolytic systems.Semantic proximity Read ↗

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.Semantic proximity Read ↗

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.Semantic proximity Read ↗

Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system.Semantic proximity Read ↗

Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.Semantic proximity Read ↗

The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.Semantic proximity Read ↗

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in MiceSemantic proximity Read ↗

Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.Semantic proximity Read ↗

Structure and function of the plasminogen/plasmin system.Semantic proximity Read ↗

COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.