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Article

COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2011

Riehl T E, He L, Zheng L, Greco S, Tollefsen D M, Stenson W F

Abstract excerpt

BACKGROUND: We found a high incidence of thrombotic deaths in COX-1(+/-)COX-2(-/-) mice and sought to define the mechanism of these events. The cyclooxygenase products thromboxane A(2) and prostacyclin are important in the regulation of coagulation but their role in fibrinolysis is largely unexplored. PAI-1 blocks fibrinolysis by inhibiting plasminogen activator. AIM: Our objective was to explain the mechanism of...

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Identifiers

PMID: 21138526
DOI: 10.1111/j.1538-7836.2010.04156.x
PMCID: PMC3687774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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