Article
Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation.
Blood - 1 Sept 2001
Kalakonda N, Rothwell D G, Scarffe J H, Norton J D
Abstract excerpt
Activating point mutations in codons 12, 13, or 61 of the K-ras and N-ras genes have been reported to occur in up to 40% of patients with multiple myeloma at presentation. In a study of 34 presentation myeloma cases using a sensitive polymerase chain reaction-restriction fragment length polymorphism strategy on enriched tumor cell populations, the present study detected N-ras codon 61 mutation-positive cells in...
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