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Article

Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background.

The Journal of clinical investigation - 1 Apr 2003

Tu Qisheng, Pi Min, Karsenty Gerard, Simpson Leigh, Liu Shiguang, Quarles L Darryl

Abstract excerpt

To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used a genetic approach to ablate parathyroid glands and remove the confounding effects of elevated parathyroid hormone (PTH) in CasR-deficient mice. CasR deficiency was transferred onto the glial cells missing 2-deficient (Gcm2-deficient) background by intercrossing CasR- and Gcm2-deficient mice. Superimposed Gcm2 deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12671052
DOI: 10.1172/JCI17054
PMCID: PMC152586

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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