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Article

Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.

Mutation research - 27 Jun 2001

Honma M, Momose M, Sakamoto H, Sofuni T, Hayashi M

Abstract excerpt

Aneuploidy is an important contributor to reproductive failure and tumor development. It arises spontaneously or as a result of exposure to aneugenic agents through non-disjunction. Two spindle poisons, colchicine (COL) and vinblastine (VBL) are mutagenic in the mouse lymphoma assay (MLA), a gene mutation assay that targets the heterozygous thymidine kinase (tk) gene on chromosome 11 in mouse lymphoma L5178Y...

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Source

Identifiers

PMID: 11516720
DOI: 10.1016/s1383-5718(01)00167-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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