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Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa

9 Jan 2025

Abstract excerpt

Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos. However, the causes of such abnormalities are unclear because no method to extract the segregated chromosomes from the blastomeres for detailed analysis. This study attempted to extract micronuclei derived from segregated chromosomes of mouse embryos....

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Identifiers

PMID: 39789115
DOI: 10.1038/s42003-024-07358-0

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