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Article

A molecular switch for specific stimulation of the BKCa channel by cGMP and cAMP kinase.

The Journal of biological chemistry - 16 Nov 2001

Zhou X B, Arntz C, Kamm S, Motejlek K, Sausbier U, Wang G X, Ruth P, Korth M

Abstract excerpt

The cGMP and the cAMP pathways control smooth muscle tone by regulation of BK(Ca) (BK) channel activity. BK channels show considerable diversity and plasticity in their regulation by cyclic nucleotide-dependent protein kinases. The underlying molecular mechanisms are unclear but may involve expression of splice variants of the BK channel alpha subunit. Three isoforms, BK(A), BK(B), and BK(C), which were cloned...

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Identifiers

PMID: 11514553
DOI: 10.1074/jbc.M104202200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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