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Article

Genetic diversity and natural selection at the domain I of apical membrane antigen-1 (AMA-1) of Plasmodium falciparum in isolates from Iran.

Experimental parasitology - 1 Apr 2012

Mardani Ahmad, Keshavarz Hossein, Heidari Aliehsan, Hajjaran Homa, Raeisi Ahmad, Khorramizadeh Mohammad Reza

Abstract excerpt

The apical membrane antigen-1 (AMA-1) of Plasmodium falciparum is a prime malaria asexual blood-stage vaccine candidate. Antigenic variation is one of the main obstacles in the development of a universal effective malaria vaccine. The extracellular region of P. falciparum AMA-1 (PfAMA-1) consists of three domains (I-III), of which the domain I is the most diverse region of this antigen. The objective of our study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22306282
DOI: 10.1016/j.exppara.2012.01.006

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