Article
Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit.
Molecular cell - 1 Jul 2001
Shou W, Sakamoto K M, Keener J, Morimoto K W, Traverso E E, Azzam R, Hoppe G J, Feldman R M, DeModena J, Moazed D, Charbonneau H, Nomura M, Deshaies R J
Abstract excerpt
The budding yeast RENT complex, consisting of at least three proteins (Net1, Cdc14, Sir2), is anchored to the nucleolus by Net1. RENT controls mitotic exit, nucleolar silencing, and nucleolar localization of Nop1. Here, we report two new functions of Net1. First, Net1 directly binds Pol I and stimulates rRNA synthesis both in vitro and in vivo. Second, Net1 modulates nucleolar structure by regulating rDNA...
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