Article
Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock.
Cell - 27 Jul 2001
Zákány J, Kmita M, Alarcon P, de la Pompa J L, Duboule D
Abstract excerpt
During development, Hox gene transcription is activated in presomitic mesoderm with a time sequence that follows the order of the genes along the chromosome. Here, we show that Hoxd1 and other Hox genes display dynamic stripes of expression within presomitic mesoderm. The underlying transcriptional bursts may reflect the mechanism that coordinates Hox gene activation with somitogenesis. This mechanism appears to...
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