Article
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
Science (New York, N.Y.) - 17 Aug 2001
Ylikorkala A, Rossi D J, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä T P
Abstract excerpt
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mesenchymal cell death, and vascular abnormalities. Extraembryonic development was also severely affected; the mutant placentas exhibited defective labyrinth layer...
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