Article
Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.
The Journal of biological chemistry - 31 May 2002
Munster Anja-K, Weinhold Birgit, Gotza Birgit, Muhlenhoff Martina, Frosch Matthias, Gerardy-Schahn Rita
Abstract excerpt
5-N-Acetylneuraminic acid (Neu5Ac) is the major sialic acid derivative found in animal cells. As a component of cell surface glycoconjugates, Neu5Ac is pivotal to numerous cellular recognition and communication processes including host-parasite interactions. A prerequisite for the synthesis of sialylated glycoconjugates is the activation of Neu5Ac to cytidine-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac)....
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