Article
Multipoint linkage analysis under heterogeneity: incorporation of parametric and nonparametric approaches.
Genetic epidemiology - 1 Jan 2001
Chiu Y F, Addington A M, Beaty T H, Klein A P, Liang K Y
Abstract excerpt
Using a recently developed multipoint parametric method, which tests for linkage in the presence of heterogeneity, we performed a genome-wide search for linkage using the German asthma data. Both dominant and recessive models were assumed in this parametric approach. Identity-by-descent (IBD) sharing for affected sibs was also calculated to help identify an appropriate genetic model and localize the trait locus....
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