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Article

Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999

das Neves L, Duchala C S, Tolentino-Silva F, Haxhiu M A, Colmenares C, Macklin W B, Campbell C E, Butz K G, Gronostajski R M, Godinho F

Abstract excerpt

The phylogenetically conserved nuclear factor I (NFI) family of transcription/replication proteins is essential both for adenoviral DNA replication and for the transcription of many cellular genes. We showed previously that the four murine NFI genes (Nfia, Nfib, Nfic, and Nfix) are expressed in unique but overlapping patterns during mouse development and in adult tissues. Here we show that disruption of the Nfia...

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Identifiers

PMID: 10518556
DOI: 10.1073/pnas.96.21.11946
PMCID: PMC18392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.PMID 10518556Read ↗

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