Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Drosophila PIAS homologue negatively regulates stat92E.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2001

Betz A, Lampen N, Martinek S, Young M W, Darnell J E

Abstract excerpt

Transcriptional activation by, and therefore the physiologic impact of, activated tyrosine-phosphorylated STATs (signal transducers and activators of transcription) may be negatively regulated by proteins termed PIAS (protein inhibitors of activated stats), as shown by previous experiments with mammalian cells in culture. Here, by using the genetic modifications in Drosophila, we demonstrate the in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye
Share to Eye Abnormalities
Share to Insect Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

Share to Morphogenesis

Share to Neoplasms, Experimental

Share to Protein-Tyrosine Kinases

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 11504941
DOI: 10.1073/pnas.171302098
PMCID: PMC55492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Drosophila PIAS homologue negatively regulates stat92E.PMID 11504941Read ↗

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and MetastasisSemantic proximity Read ↗

Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.Semantic proximity Read ↗

Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.Semantic proximity Read ↗

Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).Semantic proximity Read ↗

Transcription co-activator SAYP mediates the action of STAT activator.Semantic proximity Read ↗

chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.Semantic proximity Read ↗

Patterns and functions of STAT activation during Drosophila embryogenesis.Semantic proximity Read ↗

Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency.Semantic proximity Read ↗

Essential roles for stat92E in expanding and patterning the proximodistal axis of the Drosophila wing imaginal disc.Semantic proximity Read ↗

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.Semantic proximity Read ↗

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.Semantic proximity Read ↗

Sumoylation of Drosophila transcription factor STAT92E.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.