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Article

Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.

Frontiers in immunology - 1 Jan 2021

Järvelä-Stölting Mirva, Vesala Laura, Maasdorp Matthew K, Ciantar Joanna, Rämet Mika, Valanne Susanna

Abstract excerpt

JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrometry to analyze proteins associated with a negative regulator of the JAK/STAT pathway, and by performing a genome-wide RNAi screen, we identified several components...

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Identifiers

PMID: 35003057
DOI: 10.3389/fimmu.2021.729631
PMCID: PMC8727353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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