Article
Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2001
Shimada T, Oda Y, Gillam E M, Guengerich F P, Inoue K
Abstract excerpt
A variety of polycyclic aromatic hydrocarbons and their dihydrodiol derivatives, arylamines, heterocyclic amines, and nitroarenes, were incubated with cDNA-based recombinant (Escherichia coli or Trichoplusia ni) systems expressing different forms of human cytochrome P450 (P450 or CYP) and NADPH-P450 reductase using Salmonella typhimurium tester strain NM2009, and the resultant DNA damage caused by the reactive...
Topics
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Carcinogens
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP1B1
- Cytochrome P-450 Enzyme System
- Humans
- Polycyclic Aromatic Hydrocarbons
- Recombinant Proteins
- Salmonella typhimurium