Article
Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.
Mutation research - 20 Jan 2013
Shiizaki Kazuhiro, Kawanishi Masanobu, Yagi Takashi
Abstract excerpt
Benzo[a]pyrene (BaP) is metabolically activated by cytochrome P450 enzymes, and forms DNA adduct leading to mutations. Cytochrome P450 1A1 plays a central role in this activation step, and this enzyme is strongly induced by chemical agents that bind to the aryl hydrocarbon receptor (AhR), which i...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Animals
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cytochrome P-450 CYP1A1
- DNA Adducts
- Dioxins
- Humans
- Mice
- Mutation
- Polychlorinated Dibenzodioxins