Effects of different inducers of cytochrome P450 on the mutagenesis of the tobacco-specific nitrosamine 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) in Salmonella typhimurium TA1535.

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Article

Effects of different inducers of cytochrome P450 on the mutagenesis of the tobacco-specific nitrosamine 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) in Salmonella typhimurium TA1535.

Anticancer research - 1 Jan 2000

Teel R W

Abstract excerpt

The effects of six inducers of isoenzymes of cytochrome P450 on the mutagenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Salmonella typhimurium strain TA1535 by hamster liver S9 and microsomes were investigated. Comparisons of the effects of dimethylsulfoxide (DMSO) as solvent for NNK were also made. The inducing agents were Aroclor 1254 (AROC),...

Topics

Animals
Aroclors
Chlorodiphenyl (54% Chlorine)
Cricetinae
Cytochrome P-450 Enzyme System
Dexamethasone
Dimethyl Sulfoxide
Enzyme Induction
Ethanol
Isoenzymes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesocricetus

Methylcholanthrene

Mutation

Nitrosamines

Phenobarbital

Safrole

Salmonella typhimurium

Source

Open in PubMed

Identifiers

PMID: 1503422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1503422-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects of different inducers of cytochrome P450 on the mutagenesis of the tobacco-specific nitrosamine 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) in Salmonella typhimurium TA1535.PMID 1503422Read ↗

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