Article
Cluster effect for SNP-SNP interaction pairs for predicting complex traits.
Scientific reports - 12 Aug 2024
Lin Hui-Yi, Mazumder Harun, Sarkar Indrani, Huang Po-Yu, Eeles Rosalind A, Kote-Jarai Zsofia, Muir Kenneth R, Schleutker Johanna, Pashayan Nora, Batra Jyotsna, Neal David E, Nielsen Sune F, Nordestgaard Børge G, Grönberg Henrik, Wiklund Fredrik, MacInnis Robert J, Haiman Christopher A, Travis Ruth C, Stanford Janet L, Kibel Adam S, Cybulski Cezary, Khaw Kay-Tee, Maier Christiane, Thibodeau Stephen N, Teixeira Manuel R, Cannon-Albright Lisa, Brenner Hermann, Kaneva Radka, Pandha Hardev, Park Jong Y
Abstract excerpt
Single nucleotide polymorphism (SNP) interactions are the key to improving polygenic risk scores. Previous studies reported several significant SNP-SNP interaction pairs that shared a common SNP to form a cluster, but some identified pairs might be false positives. This study aims to identify factors associated with the cluster effect of false positivity and develop strategies to enhance the accuracy of SNP-SNP...
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