Article
Stromelysin-3 suppresses tumor cell apoptosis in a murine model.
Journal of cellular biochemistry - 1 Jan 2001
Wu E, Mari B P, Wang F, Anderson I C, Sunday M E, Shipp M A
Abstract excerpt
Stromelysin-3 (STR-3) is a matrix metalloproteinase with a unique pattern of expression and substrate specificity. During embryogenesis and remodeling of normal adult tissues, STR-3 is produced by stromal cells in direct contact with epithelial cells undergoing regional apoptosis and selective cell survival. STR-3 is also overexpressed by interdigitating stromal cells in primary epithelial malignancies. Although...
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