Article
A multiplex PCR-based DNA assay for the detection of paraoxonase gene cluster polymorphisms.
Atherosclerosis - 1 Sept 2001
Motti C, Dessì M, Gnasso A, Irace C, Indigeno P, Angelucci C B, Bernardini S, Fucci G, Federici G, Cortese C
Abstract excerpt
Paraoxonase (PON) is a high-density lipoprotein (HDL) associated protein which is supposed to protect low-density lipoprotein (LDL) against oxidation and to play a role in the development of atherosclerosis. Interindividual variability in serum PON activity is attributable to common variants in components of the PON gene cluster on chromosome 7. We describe experimental conditions that permit the simultaneous...
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