A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells.

doi:10.1046/j.1440-1711.1998.00770.x

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Article

A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells.

Immunology and cell biology - 1 Oct 1998

Shannon M F, Himes S R, Attema J

Abstract excerpt

The ability of CD4- T helper (Th) cells to differentiate into two phenotypes distinguished by their cytokine profile is a major determinant of the type of immune response elicited by bacterial, viral or parasitic infections. The development of Th1 cells is associated with delayed-type hypersensit...

Topics

Cell Differentiation
Cytokines
High Mobility Group Proteins
Interleukin-2
Interleukin-4
Phenotype
Receptors, Interleukin-2
T-Lymphocytes
Transcription, Genetic

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