Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of a single nucleotide polymorphism on the expression of human tumor necrosis factor-alpha.

Scandinavian journal of immunology - 1 Aug 2006

Lv K, Chen R, Cai Q, Fang M, Sun S

Abstract excerpt

Tumor necrosis factor (TNF)-alpha plays a prominent role in inflammations and is a proinflammatory cytokine that has been implicated in the pathogenesis of autoimmune and infectious diseases. Recent association studies have found that the TNF-alpha-857T allele was associated with several disorders. Here we demonstrate, with reporter genes under the control of the two allelic TNF-alpha promoters, that the minor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Luciferases
Share to Enzyme-Linked Immunosorbent Assay
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Spondylitis, Ankylosing

Share to Transcription, Genetic

Share to Transfection

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 16867162
DOI: 10.1111/j.1365-3083.2006.01786.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of a single nucleotide polymorphism on the expression of human tumor necrosis factor-alpha.PMID 16867162Read ↗

Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter.Semantic proximity Read ↗

[Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease].Semantic proximity Read ↗

Functional study of TNF-α promoter polymorphisms: literature review and meta-analysis.Semantic proximity Read ↗

Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter.Semantic proximity Read ↗

A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha.Semantic proximity Read ↗

Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter.Semantic proximity Read ↗

TNF-α gene polymorphisms and expressionSemantic proximity Read ↗

Functional study of TNF-α as a promoter of polymorphisms in psoriasis.Semantic proximity Read ↗

Differential association of tumour necrosis factor-alpha single nucleotide polymorphism (-308) with tuberculosis and bronchial asthma.Semantic proximity Read ↗

A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.Semantic proximity Read ↗

Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the <i>TNF</i> Promoter RegionSemantic proximity Read ↗

Polymorphism of the human TNF-alpha promoter--random variation or functional diversity?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.