Article
The response of human breast tumour cell lines with altered polymerase beta levels to cisplatin and radiation.
Anticancer research - 1 Jan 2000
Raaphorst G P, Cybulski S E, Sobol R, Ng C E
Abstract excerpt
MCF 7 (human breast carcinoma cells) and mutants transfected with the DNA polymerase beta gene were tested for response to cisplatin, radiation and combined treatments. The transfected cells showed a higher level of polymerase beta activity and were more resistant to radiation and cisplatin compared to the parental cell line. Further studies showed that for isosurvival treatments the mutant cells were more...
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