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Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice

15 Apr 2009

Abstract excerpt

Breast cancer development is a complex pathobiological process involving sequential genetic alterations in normal epithelial cells that results in uncontrolled growth in a permissive microenvironment. Accordingly, physiologically relevant models of human breast cancer that recapitulate these events are needed to study cancer biology and evaluate therapeutic agents. Here, we report the generation and utilization...

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PMID: 19369208
DOI: 10.1073/pnas.0811785106

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