Article
Correlations between p53-protein accumulation, serum antibodies and gene mutation in colorectal cancer.
International journal of cancer - 31 May 1999
Hammel P, Leroy-Viard K, Chaumette M T, Villaudy J, Falzone M C, Rouillard D, Hamelin R, Boissier B, Remvikos Y
Abstract excerpt
Only half of colorectal-cancer patients elicit serum antibodies in response to intratumoral p53-gene mutations. Our study was designed to compare cellular events (p53-protein accumulation and gene mutations) with the presence of circulating anti-p53 antibodies (p53-Ab). Thirty-five colorectal-cancer patients were studied for their intratumoral p53-protein accumulation and circulating p53-Ab. Tumour DNA was...
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