Article
Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer.
World journal of gastroenterology - 7 Aug 2013
Suppiah Aravind, Greenman John
Abstract excerpt
Mutation of the p53 gene is a key event in the carcinogenesis of many different types of tumours. These can occur throughout the length of the p53 gene. Anti-p53 auto-antibodies are commonly produced in response to these p53 mutations. This review firstly describes the various mechanisms of p53 dysfunction and their association with subsequent carcinogenesis. Following this, the mechanisms of induction of...
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