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Article

Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Wong Tania A, Fairn Gregory D, Poon Pak P, Shmulevitz Maya, McMaster Christopher R, Singer Richard A, Johnston Gerald C

Abstract excerpt

The budding yeast Saccharomyces cerevisiae contains a family of Arf (ADP-ribosylation factor) GTPase activating protein (GAP) proteins with the Gcs1 + Age2 ArfGAP pair providing essential overlapping function for the movement of transport vesicles from the trans-Golgi network. We have generated a temperature-sensitive but stable version of the Gcs1 protein that is impaired only for trans-Golgi transport and find...

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Identifiers

PMID: 16126894
DOI: 10.1073/pnas.0506156102
PMCID: PMC1200303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.PMID 16126894Read ↗

Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.Semantic proximity Read ↗

Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast.Semantic proximity Read ↗

The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.Semantic proximity Read ↗

A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.Semantic proximity Read ↗

Sec7p directs the transitions required for yeast Golgi biogenesis.Semantic proximity Read ↗

ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.Semantic proximity Read ↗

Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis.Semantic proximity Read ↗

Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast.Semantic proximity Read ↗

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.Semantic proximity Read ↗

Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation.Semantic proximity Read ↗

Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis.Semantic proximity Read ↗

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