Article
Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005
Wong Tania A, Fairn Gregory D, Poon Pak P, Shmulevitz Maya, McMaster Christopher R, Singer Richard A, Johnston Gerald C
Abstract excerpt
The budding yeast Saccharomyces cerevisiae contains a family of Arf (ADP-ribosylation factor) GTPase activating protein (GAP) proteins with the Gcs1 + Age2 ArfGAP pair providing essential overlapping function for the movement of transport vesicles from the trans-Golgi network. We have generated a temperature-sensitive but stable version of the Gcs1 protein that is impaired only for trans-Golgi transport and find...
Topics
- ADP-Ribosylation Factors
- Cell Membrane
- DNA-Binding Proteins
- Diglycerides
- Enzyme Activation
- GTPase-Activating Proteins
- Gene Expression Regulation, Fungal
- Golgi Apparatus
- Mutation
- Phospholipase D
- Phospholipid Transfer Proteins
- Protein Transport