Article
Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.
The EMBO journal - 1 Feb 1999
Poon P P, Cassel D, Spang A, Rotman M, Pick E, Singer R A, Johnston G C
Abstract excerpt
ARF proteins, which mediate vesicular transport, have little or no intrinsic GTPase activity. They rely on the actions of GTPase-activating proteins (GAPs) for their function. The in vitro GTPase activity of the Saccharomyces cerevisiae ARF proteins Arf1 and Arf2 is stimulated by the yeast Gcs1 protein, and in vivo genetic interactions between arf and gcs1 mutations implicate Gcs1 in vesicular transport. However,...
Topics
- ADP-Ribosylation Factor 1
- ADP-Ribosylation Factors
- Animals
- Biological Transport, Active
- DNA-Binding Proteins
- Endoplasmic Reticulum
- Escherichia coli
- Fungal Proteins
- GTP-Binding Proteins
- GTPase-Activating Proteins