Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Weijman Johannes F, Kumar Abhishek, Jamieson Sam A, King Chontelle M, Caradoc-Davies Tom T, Ledgerwood Elizabeth C, Murphy James M, Mace Peter D

Abstract excerpt

Apoptosis signal-regulating kinases (ASK1-3) are apical kinases of the p38 and JNK MAP kinase pathways. They are activated by diverse stress stimuli, including reactive oxygen species, cytokines, and osmotic stress; however, a molecular understanding of how ASK proteins are controlled remains obscure. Here, we report a biochemical analysis of the ASK1 kinase domain in conjunction with its N-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Phosphorylation

Share to Protein Conformation

Share to Protein Interaction Domains and Motifs

Share to Structure-Activity Relationship

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 28242696
DOI: 10.1073/pnas.1620813114
PMCID: PMC5358389

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.PMID 28242696Read ↗

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.Semantic proximity Read ↗

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer.Semantic proximity Read ↗

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.Semantic proximity Read ↗

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s DiseaseSemantic proximity Read ↗

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.Semantic proximity Read ↗

Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.Semantic proximity Read ↗

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.Semantic proximity Read ↗

The ASK1-MAP Kinase Signaling in ER Stress and Neurodegenerative DiseasesSemantic proximity Read ↗

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.Semantic proximity Read ↗

Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis.Semantic proximity Read ↗

A kinase-independent function of Ask1 in caspase-independent cell death.Semantic proximity Read ↗

Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.