Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.

Neuroscience research - 1 Jul 2010

Im Joo-Young, Lee Kang-Woo, Junn Eunsung, Mouradian M Maral

Abstract excerpt

DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regulating kinase 1 (ASK1) which is bound to and inhibited by thioredoxin 1 (Trx1) under basal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cysteine
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins

Share to Oxidative Stress

Share to Peroxiredoxins

Share to Protein Deglycase DJ-1

Share to Thioredoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 20385180
DOI: 10.1016/j.neures.2010.04.002
PMCID: PMC2883683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.PMID 20385180Read ↗

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.Semantic proximity Read ↗

Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis.Semantic proximity Read ↗

Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner.Semantic proximity Read ↗

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.Semantic proximity Read ↗

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.Semantic proximity Read ↗

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.Semantic proximity Read ↗

Modulation of signaling pathways by DJ-1: An updated overviewSemantic proximity Read ↗

Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.Semantic proximity Read ↗

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Semantic proximity Read ↗

DJ-1 has a role in antioxidative stress to prevent cell death.Semantic proximity Read ↗

Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.Semantic proximity Read ↗

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.