Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (-)-isradipine.

British journal of pharmacology - 1 Aug 2001

Berjukow S, Hering S

Abstract excerpt

Inhibition of Ca(v)1.2 by antagonist 1,4 dihydropyridines (DHPs) is associated with a drug-induced acceleration of the calcium (Ca(2+)) channel current decay. This feature is contradictorily interpreted as open channel block or as drug-induced inactivation. To elucidate the underlying molecular mechanism we investigated the effects of (+)- and (-)-isradipine on Ca(v)1.2 inactivation gating at different membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channel Blockers
Share to Calcium Channels, L-Type
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Oocytes

Share to Rabbits

Share to Stereoisomerism

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 11487504
DOI: 10.1038/sj.bjp.0704181
PMCID: PMC1572885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (-)-isradipine.PMID 11487504Read ↗

Isradipine interacts with the open state of the L-type calcium channel at high concentrations.Semantic proximity Read ↗

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca²⁺ channels revealed by Timothy syndrome mutation.Semantic proximity Read ↗

Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil.Semantic proximity Read ↗

Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel.Semantic proximity Read ↗

Molecular determinants of inactivation in voltage-gated Ca2+ channels.Semantic proximity Read ↗

Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.Semantic proximity Read ↗

Inactivation determinants in segment IIIS6 of Ca(v)3.1.Semantic proximity Read ↗

Role of Repeat I in the fast inactivation kinetics of the Ca(V)2.3 channel.Semantic proximity Read ↗

Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K+ channel, hKv1.3: implications for a second open state?Semantic proximity Read ↗

A novel molecular inactivation determinant of voltage-gated CaV1.2 L-type Ca2+ channel.Semantic proximity Read ↗

Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect.Semantic proximity Read ↗

The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.