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Article

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca²⁺ channels revealed by Timothy syndrome mutation.

European journal of pharmacology - 15 Jun 2012

Sheng Xiaona, Nakada Tsutomu, Kobayashi Motohiro, Kashihara Toshihide, Shibazaki Toshihide, Horiuchi-Hirose Miwa, Gomi Simmon, Hirose Masamichi, Aoyama Toshifumi, Yamada Mitsuhiko

Abstract excerpt

Dihydropyridine Ca(2+) channel antagonists (DHPs) block Ca(V)1.2 L-type Ca(2+) channels (LTCCs) by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear how DHPs allosterically interact with the kinetically distinct (fast and slow) VDI. Thus, we analyzed the effect of a prototypical DHP, nifedipine on LTCCs with or without the Timothy syndrome mutation that resides in the I-II...

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PMID: 22554770
DOI: 10.1016/j.ejphar.2012.04.029

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