Article
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
Science (New York, N.Y.) - 14 Sept 2001
Chamoun Z, Mann R K, Nellen D, von Kessler D P, Bellotto M, Beachy P A, Basler K
Abstract excerpt
One of the most dominant influences in the patterning of multicellular embryos is exerted by the Hedgehog (Hh) family of secreted signaling proteins. Here, we identify a segment polarity gene in Drosophila melanogaster, skinny hedgehog (ski), and show that its product is required in Hh-expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. The...
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