Article
Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes.
Current topics in developmental biology - 1 Jan 2016
Ingham Philip W
Abstract excerpt
The Nüsslein-Volhard and Wieschaus screen for mutations disrupting the segmentation of the Drosophila embryo revolutionized developmental genetics, leading the way to the identification of many of the transcription factors and signaling pathways that orchestrate development, not just in the fruit fly but across the animal kingdom. The Hedgehog signaling pathway is a case in point: yet remarkably, all but one of...
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