Article
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.) - 1 Dec 2013
Campaner Stefano, Viale Andrea, De Fazio Serena, Doni Mirko, De Franco Francesca, D'Artista Luana, Sardella Domenico, Pelicci Pier Giuseppe, Amati Bruno
Abstract excerpt
A precise balance between quiescence and proliferation is crucial for the lifelong function of hematopoietic stem cells (HSCs). Cyclins E1 and E2 regulate exit from quiescence in fibroblasts, but their role in HSCs remains unknown. Here, we report a non-redundant role for cyclin E1 in mouse HSCs. A long-term culture-initiating cell (LTC-IC) assay indicated that the loss of cyclin E1, but not E2, compromised the...
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