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Article

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

10 Nov 2008

Abstract excerpt

Notch signaling plays a role in normal lymphocyte development and function. Activating Notch1-mutations, leading to aberrant downstream signaling, have been identified in human T-cell acute lymphoblastic leukemia (T-ALL). While this highlights the contribution of Notch signaling to T-ALL pathogenesis, the mechanisms by which Notch regulates proliferation and survival in normal and leukemic T cells are not fully...

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PMID: 19001083
DOI: 10.1182/blood-2008-03-147967

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