Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rasgrp2 regulates the permissiveness of NIH3T3 cells to a herpes simplex virus 1 mutant with inactivated ICP34.5 gene.

Acta virologica - 1 Jan 2013

Xiao W, Su Y, Zhou S, Yi Ch, He G, Liu Y, Qi Y

Abstract excerpt

We have previously reported that mtHSV, a herpes simplex virus 1 (HSV-1) mutant with an inactivated gene for β-galactosidase, can efficiently lyse tumor but not normal cells. However, the mechanism of this selective oncolytic activity is so far unclear. In this study, using the phage display screening we identified the cellular protein binding to HSV-1 mutant (mtHSV) as (Ras guanyl releasing protein 2) Rasgrp2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to NIH 3T3 Cells

Share to Oncolytic Viruses

Share to Peptide Library

Share to Virus Attachment

Source

Identifiers

PMID: 23530823
DOI: 10.4149/av_2013_01_41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Rasgrp2 regulates the permissiveness of NIH3T3 cells to a herpes simplex virus 1 mutant with inactivated ICP34.5 gene.PMID 23530823Read ↗

Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3.Semantic proximity Read ↗

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.Semantic proximity Read ↗

Reovirus oncolysis: The Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infectionSemantic proximity Read ↗

The enhanced host-cell permissiveness of human cytomegalovirus is mediated by the Ras signaling pathway.Semantic proximity Read ↗

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.Semantic proximity Read ↗

Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.Semantic proximity Read ↗

Pseudorabies virus growth factor can be resolved into two active components.Semantic proximity Read ↗

Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.Semantic proximity Read ↗

Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.Semantic proximity Read ↗

Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.Semantic proximity Read ↗

Resistance of herpes simplex virus type 2 to neomycin maps to the N-terminal portion of glycoprotein C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.