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Article

Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.

Journal of virology - 1 Feb 2006

Smith Kerrington D, Mezhir James J, Bickenbach Kai, Veerapong Jula, Charron Jean, Posner Mitchell C, Roizman Bernard, Weichselbaum Ralph R

Abstract excerpt

Herpes simplex virus mutants lacking the gamma(1)34.5 gene are not destructive to normal tissues but are potent cytolytic agents in human tumor cells in which the activation of double-stranded RNA-dependent protein kinase (PKR) is suppressed. Thus, replication of a Deltagamma(1)34.5 mutant (R3616) in 12 genetically defined cancer cell lines correlates with suppression of PKR but not with the genotype of RAS....

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Source

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Identifiers

PMID: 16414988
DOI: 10.1128/JVI.80.3.1110-1120.2006
PMCID: PMC1346955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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