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Oncogenic Ras Promotes Reovirus Spread by Suppressing IFN-β Production through Negative Regulation of <i>RIG-I</i> Signaling

25 May 2010

Abstract excerpt

Reovirus is the first naturally occurring human virus reported to exploit activated Ras signaling in the host cell for infection, and is currently undergoing clinical trials as a cancer therapeutic. Recent evidence suggests that Ras transformation promotes three reoviral replication steps during the first round of infection: uncoating of the incoming virion, generation of progeny viruses with enhanced...

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PMID: 20501842
DOI: 10.1158/0008-5472.can-09-4676

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