Article
Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.
Blood cells, molecules & diseases - 1 Jan 2000
Rapoport A P, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle P M, Nahm M, Insel R A, Abboud C N
Abstract excerpt
Burkitt's lymphoma cell lines have been important in vitro models for studying the pathogenesis of Burkitt's lymphoma (BL) and for exploring new treatment strategies. A new EBV(-) Burkitt's lymphoma cell line (GA-10) was established from a patient with a clinically aggressive, chemorefractory BL and characterized. Although functional p-glycoprotein could not be demonstrated by dye-efflux assays, both p53 genes...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Antineoplastic Agents
- Apoptosis
- Burkitt Lymphoma
- Caspase 3
- Caspases
- Cell Division
- Dose-Response Relationship, Drug
- Enzyme Activation
- Flavonoids
- Genes, p53