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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

1 Jun 2008

Abstract excerpt

The natural product gambogic acid (GA) has been reported to have cytotoxic activity against tumor cells in culture and was identified as an active compound in a cell-based high-throughput screening assay for activators of caspases, proteases involved in apoptosis. Using the antiapoptotic Bcl-2 family protein, Bfl-1, as a target for screening of a library of natural products, we identified GA as a competitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18566235
DOI: 10.1158/1535-7163.mct-07-2373

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