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Article

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.

Cancer chemotherapy and pharmacology - 1 Jan 1997

An W G, Schnur R C, Neckers L, Blagosklonny M V

Abstract excerpt

PURPOSE: Recently, it has been shown that geldanamycin (GA), a benzoquinone ansamycin, is able to deplete mutant p53, p185erbB2 and Raf-1 proteins in cancer cells. However, the relationship between these activities of GA and its antiproliferative activity is not clear. Here we investigated the effects of 28 GA derivatives in SKBr3, a human breast cancer cell line. METHODS: We performed Western blot analysis of...

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Source

Identifiers

PMID: 9137531
DOI: 10.1007/s002800050626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.PMID 9137531Read ↗

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Geldanamycin selectively destabilizes and conformationally alters mutated p53.Semantic proximity Read ↗

Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.Semantic proximity Read ↗

The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines.Semantic proximity Read ↗

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