A novel flow cytometric method for the quantification of p53 gene expression.

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Article

A novel flow cytometric method for the quantification of p53 gene expression.

Cytometry - 1 Mar 1998

Filippini G, Griffin S, Uhr M, Eppenberger H, Bonilla J, Cavalli F, Soldati G

Abstract excerpt

We describe a rapid and simple flow cytometry technique for the detection and quantification of p53 in several human cell lines, including an adenocarcinoma cell line (SW 626) having a mutant (m) p53, and a pre-B leukemia cell line (NALM-6) having wild-type (wt) p53. By introducing a second antib...

Topics

Adenocarcinoma
Antibodies, Monoclonal
Antineoplastic Agents
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Fluorescent Antibody Technique, Indirect
Gene Expression
Genes, p53
Humans
Leukemia
Lymphoma
Mutation
Sensitivity and Specificity
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9515717

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9515717-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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