Article
Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Jan 2021
Wu Yih-Ru, Chang Kuo-Hsuan, Chao Chih-Ying, Lin Chih-Hsin, Chen Yi-Chun, Liu Tsai-Wei, Lee-Chen Guey-Jen, Chen Chiung-Mei
Abstract excerpt
BACKGROUND: Oxidative stress could participate in the pathogenesis of Parkinson's disease (PD). However, the role of genetic variation of superoxide dismutase 2 (SOD2), an important regulator against oxidative stress, in PD remains to be elucidated. METHODS: We screened SOD2 gene variation by sequencing cDNA from 72 patients with early onset PD. A cohort of PD (n = 609) and ethnically matched controls (n = 681)...
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