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Article

A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson's disease.

Pharmacogenetics and genomics - 1 Sept 2011

Ayuso Pedro, Martínez Carmen, Lorenzo-Betancor Oswaldo, Pastor Pau, Luengo Antonio, Jiménez-Jiménez Félix J, Alonso-Navarro Hortensia, Villalba Maria T, Agúndez José A G, García-Martín Elena

Abstract excerpt

AIM: Oxidative stress and iron deposition is related to Parkinson's disease (PD). Heme oxygenase 2 (HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide. This study aims to analyze variations in the HMOX2 gene in patients with PD. MATERIALS AND METHODS: We mapped four single nucleotide polymorphisms (SNPs) and copy number variations of the HMOX2 gene in 691...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21709601
DOI: 10.1097/FPC.0b013e328348f729

Genes

HMOX2

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