Article
Genetic variation of superoxide dismutases in patients with primary open-angle glaucoma.
Ophthalmic genetics - 1 Jun 2014
Celojevic Dragana, Nilsson Staffan, Kalaboukhova Lada, Tasa Gunnar, Juronen Erkki, Sjölander Annica, Zetterberg Henrik, Zetterberg Madeleine
Abstract excerpt
PURPOSE: Oxidative stress has been described as an underlying pathogenetic mechanism in retinal ganglion cell apoptosis, which is a hallmark of primary open-angle glaucoma (POAG). Superoxide dismutases (SODs) are enzymes involved in the protection against oxidative stress by detoxification of superoxide. In this study, we investigated a number of disease-associated single nucleotide polymorphisms (SNPs) in the...
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