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Article

Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.

Neurobiology of aging - 1 Jun 2013

Brighina Laura, Riva Chiara, Bertola Francesca, Saracchi Enrico, Fermi Silvia, Goldwurm Stefano, Ferrarese Carlo

Abstract excerpt

Generation of reactive oxygen species during dopamine (DA) oxidation could be one of the factors leading to the selective loss of nigral dopaminergic neurons in Parkinson's disease (PD). Vesicular monoamine transporter type 2 (VMAT2) proteins in nerve terminals uptake dopamine into synaptic vesicles, preventing its cytoplasmic accumulation and toxic damage to nigral neurons. Polymorphisms in VMAT2 gene and in its...

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Identifiers

PMID: 23369548
DOI: 10.1016/j.neurobiolaging.2012.12.020
PMCID: PMC3605583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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