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Article

Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.

Molecular and cellular neurosciences - 1 May 2010

Portella Aline Cristina, Carvalho Fernando, Faustino Larissa, Wondisford Fredric E, Ortiga-Carvalho Tânia Maria, Gomes Flávia Carvalho Alcantara

Abstract excerpt

Cerebellar development on the postnatal period is mainly characterized by cellular proliferation in the external granular layer (EGL) followed by migration of granular cells in the molecular layer through the Bergmann glia (BG) fibers in order to form the granular layer in the adult. All these events are drastically affected by thyroid hormones (TH), which actions are mainly mediated by alpha (TRalpha) and beta...

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PMID: 20193766
DOI: 10.1016/j.mcn.2010.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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